AK-068

• Description :

  AK-068 is a STAT6 ligand, with a Ki of 6 nM and at least >85-fold binding selectivity over STAT5. AK-068 is a ligand for target protein (STAT6) for PROTAC (HY-169179) [1].

• UNSPSC :

  12352005

• Target :

  Ligands for Target Protein for PROTAC; STAT

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ak-068.html

• Purity :

  99.57

• Solubility :

  DMSO : 100 mg/mL

• Smiles :

  FC(C1=CC=C2C(C=C(C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N4C[C@@H](C5=CC=CC=C5)OCC4)=O)CCC3)=O)=O)S2)=C1)(P(O)(O)=O)F

• Molecular Formula :

  C31H36F2N3O7PS

• Molecular Weight :

  663.67

• References & Citations :

  [1]Kaneshige A, et, al. Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader. J Med Chem. 2024 Sep 23.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  STAT6

• CAS Number :

  [2982851-09-0]