AK-068

• UNSPSC Description:

  AK-068 is a STAT6 ligand, with a Ki of 6 nM and at least >85-fold binding selectivity over STAT5. AK-068 is a ligand for target protein (STAT6) for PROTAC (HY-169179)[1].

• Target Antigen:

  Ligands for Target Protein for PROTAC

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ak-068.html

• Smiles:

  FC(C1=CC=C2C(C=C(C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N4C[C@@H](C5=CC=CC=C5)OCC4)=O)CCC3)=O)=O)S2)=C1)(P(O)(O)=O)F

• Molecular Weight:

  663.67

• References & Citations:

  [1]Kaneshige A, et, al. Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader. J Med Chem. 2024 Sep 23.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2982851-09-0