AK-068

CAT: 0804-HY-169182-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-169182-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AK-068 is a STAT6 ligand, with a Ki of 6 nM and at least >85-fold binding selectivity over STAT5. AK-068 is a ligand for target protein (STAT6) for PROTAC (HY-169179) [1].
CAS Number
[2982851-09-0]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ak-068.html
Purity
99.57
Solubility
DMSO : 100 mg/mL
Smiles
FC(C1=CC=C2C(C=C(C(N[C@@H](C(C)(C)C)C(N3[C@H](C(N4C[C@@H](C5=CC=CC=C5)OCC4)=O)CCC3)=O)=O)S2)=C1)(P(O)(O)=O)F
Molecular Formula
C31H36F2N3O7PS
Molecular Weight
663.67
References & Citations
[1]Kaneshige A, et, al. Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader. J Med Chem. 2024 Sep 23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT6

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