AK-7

• Description:

  AK-7 is a selective cell- and brain-permeable SIRT2 inhibitor, with an IC50 of 15.5 μM.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Sirtuin

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/AK-7.html

• Concentration:

  10mM

• Purity:

  99.63

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  O=S (N1CCCCCC1) (C2=CC (C (NC3=CC (Br) =CC=C3) =O) =CC=C2) =O

• Molecular Formula:

  C19H21BrN2O3S

• Molecular Weight:

  437.35

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Taylor DM, et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem Biol. 2011 Jun 17;6 (6) :540-6.|[2]Chopra V, et al. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2012 Dec 27;2 (6) :1492-7.|[3]Szego EM, et al. Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway. Neurobiol Aging. 2017 Aug;56:7-16.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  SIRT2

• CAS Number:

  420831-40-9