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Lycorine (hydrochloride)

CAT: 0804-HY-N0289-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0289-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity[1]. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM) [2].
CAS Number
2188-68-3
UNSPSC
12352005
Hazard Statement
H301
Target
Autophagy; Bacterial; Virus Protease
Type
Natural Products
Related Pathways
Anti-infection; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Lycorine-hydrochloride.html
Purity
99.89
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4.Cl
Molecular Formula
C16H18ClNO4
Molecular Weight
323.77
Precautions
H301
References & Citations
[1]Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012) .|[2]Cao, Z. et al.Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity. Toxicology letters 218, 174-185, doi:10.1016/j.toxlet.2013.01.018 (2013) .
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Citation 01
BioRxiv. 2024 Feb 6:2024.02.06.579103.|Cancers (Basel) . 2025 Feb 20;17 (5) :718.|Patent. US20230014181.|Preprints. 2024 Nov.|Ann Hematol. 2023 May;102 (5) :1073-1086.|Antiviral Res. 2024 Jul 2:228:105955.|Eur J Pharmacol. 2023 Dec 15:961:176162.|Int J Mol Med. 2022 Dec;50 (6) :145.|Int J Mol Sci. 2025 Jun 3;26 (11) :5358.|J Exp Clin Cancer Res. 2022 Mar 30;41 (1) :116.|Microorganisms. 2022 Oct 21;10 (10) :2089.|Mol Med Rep. 2024 Mar;29 (3) :48.|Oncol Lett. 2021 Nov;22 (5) :781.|Pharmacol Res. 2022 Jan:175:105985.|Research Square Preprint. 2022 Feb.|Research Square Preprint. 2022 Jan.

Chemical Information

Lycorine hydrochloride

See also: Lycorine (annotation moved to).

CAS Number2188-68-3
PubChem CID164943
IUPAC Name(1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol;hydrochloride
Molecular FormulaC16H18ClNO4
Molecular Weight323.77
Topological Polar Surface Area62.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Heavy Atom Count22
Formal Charge0
Complexity481
SMILES
C1CN2CC3=CC4=C(C=C3[C@H]5[C@H]2C1=C[C@@H]([C@H]5O)O)OCO4.Cl
InChI
InChI=1S/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1
InChIKey
VUVNTYCHKZBOMV-NVJKKXITSA-N
Chemical Structure
2D Structure
2D structure of Lycorine hydrochloride
CAS: 2188-68-3
CID: 164943
Formula: C16H18ClNO4
MW: 323.77
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight323.77
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Exact Mass323.0924357
Monoisotopic Mass323.0924357
Topological Polar Surface Area62.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity481
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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