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Lycorine

CAT: 0804-HY-N0288-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0288-01Size:50 mg
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Description
Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription[2]. Lycorine is also a melanoma vasculogenic inhibitor[3]. Lycorine can be used for the study of prostate cancer and metabolic diseases[2].
CAS Number
[476-28-8]
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Bacterial; Fatty Acid Synthase (FASN) ; Virus Protease
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lycorine.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4
Molecular Formula
C16H17NO4
Molecular Weight
287.31
Precautions
H301
References & Citations
[1]Hu M, et al.Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer.Oncotarget. 2015 Jun 20;6 (17) :15348-61.|[2]Zu-Guo Zheng, et al. Discovery of a Potent SCAP Degrader That Ameliorates HFD-induced Obesity, Hyperlipidemia and Insulin Resistance via an Autophagy-Independent Lysosomal Pathway. Autophagy. 2020 May 20;1-22.|[3][1].Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012) .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Citation 01
Ann Hematol. 2023 May;102 (5) :1073-1086.|Antiviral Res. 2024 Jul 2:228:105955.|Eur J Pharmacol. 2023 Dec 15:961:176162.|Int J Mol Med. 2022 Dec;50 (6) :145.|Int J Mol Sci. 2025 Jun 3;26 (11) :5358.|J Exp Clin Cancer Res. 2022 Mar 30;41 (1) :116.|Microorganisms. 2022 Oct 21;10 (10) :2089.|Mol Med Rep. 2024 Mar;29 (3) :48.|Oncol Lett. 2021 Nov;22 (5) :781.|Pharmacol Res. 2022 Jan:175:105985.|Research Square Preprint. 2022 Feb.|Research Square Preprint. 2022 Jan.|bioRxiv. 2024 Feb 6:2024.02.06.579103.|Cancers (Basel) . 2025 Feb 20;17 (5) :718.|Patent. US20230014181.|Preprints. 2024 Nov.

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