Products for Research Use Only
RegisterLogin

KY-226

CAT: 0804-HY-120327-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-120327-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 0.25 μM, and without PPARγ agonist activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 also protects neurons from cerebral ischemic injury[1][2].
CAS Number
1621673-53-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ky-226.html
Concentration
10mM
Purity
98.42
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1
Molecular Formula
C27H31NO3S2
Molecular Weight
481.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Ito Y, et al. Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice. J Pharmacol Sci. 2018 May;137 (1) :38-46.|[2]Sun M, et al. KY-226 Protects Blood-brain Barrier Function Through the Akt/FoxO1 Signaling Pathway in Brain Ischemia. Neuroscience. 2019 Feb 10;399:89-102.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-124764KY-04031
HY-117218KY-04045
HY-167664KY-455
HY-124156KY-02327
HY-113773KY-9
HY-124745-01KY-05009
HY-U00148-01KY-556
HY-117842KY 234
HY-P99431-01KY-1044
HY-124156A-01KY-02327 (acetate)

Alternative Products

CatalogName
MBS3610912-01KY-226
566859-01KY
037653KY, NT (KY, Kyphoscoliosis peptidase)
MBS6314975-01KY, NT (KY, Kyphoscoliosis peptidase) (AP)
BA2865-10KY-05009
T201482-01KY-455
453086-01KY 02111
T39508-01KY-02327
MBS7104433-01KY Antibody
27759-1KY 2111

Popular Products