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Tacrolimus (Standard)

CAT: 0804-HY-13756R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13756R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tacrolimus (Standard) is the analytical standard of Tacrolimus. This product is intended for research and analytical applications. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].
CAS Number
104987-11-3
Product Name Alternative
FK506 (Standard) ; Fujimycin (Standard) ; FR900506 (Standard)
UNSPSC
12352005
Hazard Statement
H301, H361, H372
Target
Antibiotic; Autophagy; Bacterial; FKBP; Phosphatase; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tacrolimus-standard.html
Purity
99.60
Smiles
O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC=C)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O
Molecular Formula
C44H69NO12
Molecular Weight
804.02
Precautions
H301, H361, H372
References & Citations
[1]Thomson AW, et al. Mode of action of Tacrolimus (FK506) : molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17 (6) :584-91.|[2]Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39 (6) :877-886.|[3]Zhu H, et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF 1α expression in vivo. Mol Med Rep. 2014 Aug;10 (2) :585-92.|[4]Okada Y, et al. Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interleukin-1β suppression. Biol Pharm Bull. 2011;34 (12) :1823-7.|[5]Yuwei He, et al. Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis. Nano Res. 30 June 2018.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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