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Tacrolimus-13C, d2

CAT: 0804-HY-13756SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13756SSize:1 mg
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Description
Tacrolimus-13C, d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].
CAS Number
1356841-89-8
Product Name Alternative
FK506-13C, d2; Fujimycin-13C, d2; FR900506-13C, d2
UNSPSC
12352005
Hazard Statement
H301
Target
Antibiotic; Autophagy; Bacterial; FKBP; Phosphatase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer; Infection; Inflammation/Immunology
Purity
98.36
Solubility
DMF : ≥ 30mg/mL|DMSO : ≥ 20mg/mL|Ethanol : ≥ 30mg/mL
Smiles
O=C(O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(C)=C/[C@H]2C[C@H]([C@@H](CC2)O)OC)[C@]3([H])CCCCN3C(C([C@]4([C@@H](C[C@@H]([C@@]([H])([C@H](C[C@H](C/C(C)=C/[C@H]1C/C=[13C]([2H])\[2H])C)OC)O4)OC)C)O)=O)=O
Molecular Formula
C43 13CH67D2NO12
Molecular Weight
807.02
Precautions
H301
References & Citations
[1]Thomson AW, et al. Mode of action of Tacrolimus (FK506) : molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17 (6) :584-91.; Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcri|[2]Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39 (6) :877-886.|[3]A W Thomson, et al. Mode of action of Tacrolimus (FK506) : molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17 (6) :584-91.; Vogel KR
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Macrolide

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Alternative Products

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CS-O-49017Tacrolimus-13C, d5
CS-O-13614Tacrolimus-13C, d4
CS-O-03122Tacrolimus-13C, d2
TMIH-0548Tacrolimus-13C-d2
RM-T031254-01Tacrolimus-13C-D4
ESS0447-01Tacrolimus-13C, D2 (major)
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291021FK-506 (Fujimycin, Tacrolimus) -13C, D2
TRC-F370002-0.5MGFK-506-13C,D2 (Major) (Tacrolimus) (>85%)
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