Tacrolimus-d3

CAT: 0804-HY-13756S2Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-13756S2Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Tacrolimus-d3 (FK506-d3) is deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].
Product Name Alternative
FK506-d3; Fujimycin-d3; FR900506-d3
UNSPSC
12352005
Target
Antibiotic; Autophagy; Bacterial; FKBP; Isotope-Labeled Compounds; Phosphatase
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Smiles
O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/C3([2H])CC=C)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)C([2H])([2H])C3=O
Molecular Formula
C44H66D3NO12
Molecular Weight
807.04
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Thomson AW, et al. Mode of action of Tacrolimus (FK506) : molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17 (6) :584-91.|[3]Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39 (6) :877-886.|[4]Zhu H, et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF 1α expression in vivo. Mol Med Rep. 2014 Aug;10 (2) :585-92.|[5]Okada Y, et al. Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interleukin-1β suppression. Biol Pharm Bull. 2011;34 (12) :1823-7.|[6]Yuwei He, et al. Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis. Nano Res. 30 June 2018.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-13756-01Tacrolimus
HY-13756R-01Tacrolimus (Standard)
HY-161560Tacrolimus/BSA
HY-13756A-01Tacrolimus (monohydrate)
HY-13756STacrolimus-13C, d2
HY-Z8754-01Tacrolimus 8-epimer
HY-13756ARTacrolimus (monohydrate) (Standard)
HY-15491613-O-Desmethyl tacrolimus
HY-144920S-01Tacrolimus impurity 16-13C, d2
HY-15398S3-01Vitamin D3-d3

Alternative Products

CatalogName
JL52716-01Tacrolimus (Tacrolimus) ELISA Kit
227173Tacrolimus (Tacrolimus 22) (HRP)
E4A10W15Tacrolimus
RM-T031205-01Tacrolimus Diene; Tacrolimus EP Impurity I
JH56947Tacrolimus Monohydrate
MBS5304262-01Tacrolimus-HRP
F001-10MGFK506 (Tacrolimus)
100795Tacrolimus anhydrous
C17572Tacrolimus (FK506)

Popular Products