2,8-Dihydroxyadenine

• Description:

  2,8-Dihydroxyadenine, an endogenous metabolite, can cause the formation of urinary crystals and kidney stones. 2,8-Dihydroxyadenine can be used to diagnose adenine phosphoribosyltransferase (APRT) deficiency[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/2-8-dihydroxyadenine.html

• Purity:

  98.53

• Solubility:

  H2O : 2.2 mg/mL (ultrasonic; warming)

• Smiles:

  O=C1NC2=C (NC (N2) =O) C (N) =N1

• Molecular Formula:

  C5H5N5O2

• Molecular Weight:

  167.13

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Ceballos-Picot I, et, al. 2,8-Dihydroxyadenine urolithiasis: a not so rare inborn error of purine metabolism. Nucleosides Nucleotides Nucleic Acids. 2014;33 (4-6) :241-52.|[2]Sreejith P, et, al. 2, 8 Dihydroxyadenine urolithiasis: A case report and review of literature. Indian J Nephrol. 2009 Jan;19 (1) :34-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  30377-37-8