MNK1/2-IN-8
CAT:
804-HY-158438
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MNK1/2-IN-8
- CAS Number: 2430793-35-2
- UNSPSC Description: MNK1/2-IN-8 (compound 15b) is a MNK1/2 inhibitor with the IC50 values of 0.8 and 1.5 nM against Mnk1 and Mnk2. MNK1/2-IN-8 shows anti-proliferative activity and induces cell cycle arrest[1].
- Target Antigen: MNK
- Type: Reference compound
- Related Pathways: MAPK/ERK Pathway
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/mnk1-2-in-8.html
- Smiles: O=C(N1CCNCC1)C2=CC=CC(C3=NC4=C(N=CN=C4N5CCC6=C5C=CC=C6)C=C3)=C2
- Molecular Weight: 436.51
- References & Citations: [1]Xing K, Zhang H, Wang S, et al. Design, synthesis and biological evaluation of 4-(indolin-1-yl)-6-substituted-pyrido[3,2-d]pyrimidine derivatives as Mnk1/2 inhibitors. Eur J Med Chem. 2024;272:116499.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported