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Mavacamten (Standard)

CAT: 0804-HY-109037R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109037R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mavacamten (Standard) is the analytical standard of Mavacamten. This product is intended for research and analytical applications. Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
CAS Number
1642288-47-8
Product Name Alternative
MYK461 (Standard) ; SAR439152 (Standard)
UNSPSC
12352005
Target
Myosin; Reference Standards
Type
Reference Standards
Related Pathways
Cytoskeleton; Others
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mavacamten-standard.html
Purity
99.74
Smiles
CC(N(C1=O)C(C=C(N[C@H](C2=CC=CC=C2)C)N1)=O)C
Molecular Formula
C15H19N3O2
Molecular Weight
273.33
References & Citations
[1]Kawas RF, et al. A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Oct 6;292 (40) :16571-16577.|[2]Stern JA, et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11 (12) :e0168407.|[3]Green EM, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351 (6273) :617-21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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