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Mavacamten-d6

CAT: 0804-HY-109037SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109037SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mavacamten-d6 (MYK461-d6; SAR439152-d6) is deuterium labeled Mavacamten. Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
CAS Number
2453251-18-6
Product Name Alternative
MYK461-d6; SAR439152-d6
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Myosin
Type
Isotope-Labeled Compounds
Related Pathways
Cytoskeleton; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C(N1C(C=C(NC1=O)N[C@H](C2=CC=CC=C2)C)=O)C([2H])([2H])[2H]
Molecular Formula
C15H13D6N3O2
Molecular Weight
279.37
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kawas RF, et al. A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Oct 6;292 (40) :16571-16577.|[3]Stern JA, et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11 (12) :e0168407.|[4]Green EM, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351 (6273) :617-21.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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