Mavacamten

CAT: 0804-HY-109037-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-109037-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
CAS Number
[1642288-47-8]
Product Name Alternative
MYK461; SAR439152
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Mavacamten.html
Purity
99.98
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
CC(N(C1=O)C(C=C(N[C@H](C2=CC=CC=C2)C)N1)=O)C
Molecular Formula
C15H19N3O2
Molecular Weight
273.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Kawas RF, et al. A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Oct 6;292 (40) :16571-16577.|[2]Stern JA, et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11 (12) :e0168407.|[3]Green EM, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351 (6273) :617-21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Alternative Products

CatalogName
M12489-01Mavacamten
TRC-M299820-100MGEnt-Mavacamten
TRC-H299820-10MGHydroxy Mavacamten
A19326-1Mavacamten 1mg
TRC-M299811-5MGMavacamten-d7
A19326-25Mavacamten 25mg
A19326-100Mavacamten 100mg
A19326-10Mavacamten 10mg
A19326-50Mavacamten 50mg
A19326-5Mavacamten 5mg

Popular Products