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Mavacamten-d5

CAT: 0804-HY-109037S3-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109037S3-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mavacamten-d5 (MYK461-d5; SAR439152-d5) is deuterium labeled Mavacamten. Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
CAS Number
2453251-00-6
Product Name Alternative
MYK461-d5; SAR439152-d5
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Myosin
Type
Isotope-Labeled Compounds
Related Pathways
Cytoskeleton; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
98.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1C(C=C(NC1=O)N[C@H](C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C)=O)C
Molecular Formula
C15H14D5N3O2
Molecular Weight
278.36
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kawas RF, et al. A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Oct 6;292 (40) :16571-16577.|[3]Stern JA, et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11 (12) :e0168407.|[4]Green EM, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351 (6273) :617-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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