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DHPS-IN-1

CAT: 0804-HY-115712-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115712-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHPS-IN-1, with the best DHPS inhibitory potency (IC50 = 0.014 μM), exhibits excellent inhibition against melanoma cells.
CAS Number
2643300-54-1
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dhps-in-1.html
Purity
99.78
Solubility
DMSO : 86.67 mg/mL (ultrasonic; warming; adjust pH to 8 with 1 M NaOH; heat to 60°C)
Smiles
NC1=NC(C2=CC=C(Br)C=C2)=NC(Cl)=C1OC3=CC=CC=C3OC
Molecular Formula
C17H13BrClN3O2
Molecular Weight
406.66
References & Citations
[1]Liu KL, et al. Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation. J Med Chem. 2021 Sep 23;64 (18) :13356-13372.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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