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DHPS-IN-2

CAT: 804-HY-175828Size: 1 EachDry Ice: NoHazardous: No
1 EachSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHPS-IN-2 is an allosteric deoxyhypusine synthase (DHPS) inhibitor with an IC50 of 70 nM and a Kd of 26.4 μM. DHPS-IN-2 significantly suppresses melanoma cell migration and invasiveness in vitro and exhibits potent anti-tumor efficacy in an A375 cell zebrafish xenograft model. DHPS-IN-2 can be used for the study of melanoma[1].
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
IC1=CC=C(C=C1)CC2=NN=C(CC3=CC=CC=C3OC)O2
Molecular Formula
C17H15IN2O2
Molecular Weight
406.22
References & Citations
[1]Liu KL, et al. In silico design, synthesis and biological evaluation of 2-benzyl-5- (2-methoxybenzyl) -1,3,4-oxadiazole derivates as allosteric deoxyhypusine synthase (DHPS) inhibitors for melanoma treatment. Eur J Med Chem. 2025 Dec 5;299:118061.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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