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DHPG

CAT: 0804-HY-12598A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12598A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHPG is the agonist for mGluR 1/5 (EC50 for mGluR 1 is 60 nM) that activates the phospholipase C (PLC) pathway, and leads ultimately to the activation of protein kinase C (PKC) [1].
CAS Number
[146255-66-5]
Product Name Alternative
(RS) -3,5-DHPG
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dhpg.html
Purity
99.60
Solubility
DMSO : 33.33 mg/mL (ultrasonic; adjust pH to 2 with HCl) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C(N)C1=CC(O)=CC(O)=C1
Molecular Formula
C8H9NO4
Molecular Weight
183.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Winder DG, et al. Metabotropic glutamate receptor (mGluR) -mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J Neurochem. 1995 Feb;64 (2) :592-9.|[2]Pellegrini-Giampietro DE, et al. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br J Pharmacol. 1996 Jun;118 (4) :1035-43.|[3]Scotland PE, et al., Enhanced 3,5-dihydroxyphenylglycine-induced sustained nociceptive behaviors in rats with neuropathy or chronic inflammation. Behav Brain Res. 2007 Dec 3;184 (2) :150-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1; mGluR5

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