Thalidomide-5-propargyne-NH2 (hydrochloride)

• UNSPSC Description:

  Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].

• Target Antigen:

  Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-5-propargyne-nh2-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=CC=C(C=C2C(N1C3C(NC(CC3)=O)=O)=O)C#CCN.Cl

• Molecular Weight:

  347.75

• References & Citations:

  [1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2490402-62-3