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N3-PEG4-C2-NH2

CAT: 0804-HY-128834-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128834-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N3-PEG4-C2-NH2 (PROTAC Linker 20) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. N3-PEG4-C2-NH2 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
951671-92-4
Product Name Alternative
PROTAC Linker 20
UNSPSC
12352211
Hazard Statement
H314
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-linker-20.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCOCCOCCOCCOCCN=[N+]=[N-]
Molecular Formula
C10H22N4O4
Molecular Weight
262.31
Precautions
H314
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

Chemical Information

Azido-PEG4-Amine
CAS Number951671-92-4
PubChem CID71313220
IUPAC Name2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanamine
Molecular FormulaC10H22N4O4
Molecular Weight262.31
XLogP-0.4
Topological Polar Surface Area77.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count14
Heavy Atom Count18
Formal Charge0
Complexity212
SMILES
C(COCCOCCOCCOCCN=[N+]=[N-])N
InChI
InChI=1S/C10H22N4O4/c11-1-3-15-5-7-17-9-10-18-8-6-16-4-2-13-14-12/h1-11H2
InChIKey
ZMBGKXBIVYXREN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azido-PEG4-Amine
CAS: 951671-92-4
CID: 71313220
Formula: C10H22N4O4
MW: 262.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight262.31
XLogP3-0.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count14
Exact Mass262.16410520
Monoisotopic Mass262.16410520
Topological Polar Surface Area77.3 Ų
Heavy Atom Count18
Formal Charge0
Complexity212
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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