NH2-C5-PEG4-N3-L-Lysine-PEG3-N3

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3

• UNSPSC Description: NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
• Target Antigen: ADC Linker
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/nh2-c5-peg4-n3-l-lysine-peg3-n3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@H](CCCCN)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)NCCOCCOCCOCCN=[N+]=[N-]
• Molecular Weight: 619.71
• References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported