Ezetimibe phenoxy glucuronide-d4

Ezetimibe phenoxy glucuronide-d4

• CAS Number: 1426174-41-5
• UNSPSC Description: Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].
• Target Antigen: Drug Metabolite
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Metabolic Disease
• Smiles: O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=C([C@H]([C@H]3CC[C@@H](C4=CC=C(F)C=C4)O)N(C5=C([2H])C([2H])=C(F)C([2H])=C5[2H])C3=O)C=C2
• Molecular Weight: 589.57
• References & Citations: [1]Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11.|[2]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.
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