Ezetimibe phenoxy glucuronide

• Description :

  Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].

• Product Name Alternative :

  Ezetimibe glucuronide; Ezetimibe β-D-glucuronide

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Drug Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/ezetimibe-phenoxy-glucuronide.html

• Purity :

  99.77

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=C([C@H]([C@H]3CC[C@@H](C4=CC=C(F)C=C4)O)N(C5=CC=C(F)C=C5)C3=O)C=C2

• Molecular Formula :

  C30H29F2NO9

• Molecular Weight :

  585.55

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4 (7) :908-11.|[2]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [190448-57-8]