Ezetimibe phenoxy glucuronide

CAT: 0804-HY-135391-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-135391-01Size:1 mg
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Description
Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].
CAS Number
[190448-57-8]
Product Name Alternative
Ezetimibe glucuronide; Ezetimibe β-D-glucuronide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ezetimibe-phenoxy-glucuronide.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC=C([C@H]([C@H]3CC[C@@H](C4=CC=C(F)C=C4)O)N(C5=CC=C(F)C=C5)C3=O)C=C2
Molecular Formula
C30H29F2NO9
Molecular Weight
585.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4 (7) :908-11.|[2]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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