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Ezetimibe-d4-1

CAT: 0804-HY-17376S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17376S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ezetimibe-d4-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
CAS Number
1093659-89-2
Product Name Alternative
SCH 58235-d4-1
UNSPSC
12352005
Target
Autophagy; Keap1-Nrf2
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cardiovascular Disease; Cancer
Purity
99.26
Solubility
10 mM in DMSO|DMSO : 200mg/mL (ultrasonic) |H2O : 0.1mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC=C([C@@H]2[C@H](C(N2C3=CC=C(C=C3)F)=O)CC[C@@H](C4=C(C([2H])=C(C([2H])=C4[2H])F)[2H])O)C=C1
Molecular Formula
C24H17D4F2NO3
Molecular Weight
413.45
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21 (25) :7754-63.|[3]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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