Ezetimibe-d4-1

• UNSPSC Description:

  Ezetimibe-d4-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

• Target Antigen:

  Autophagy; Keap1-Nrf2

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Autophagy;NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cardiovascular Disease; Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC=C([C@@H]2[C@H](C(N2C3=CC=C(C=C3)F)=O)CC[C@@H](C4=C(C([2H])=C(C([2H])=C4[2H])F)[2H])O)C=C1

• Molecular Weight:

  413.45

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Chang E, et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7;21(25):7754-63.|[3]Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  1093659-89-2