Ezetimibe hydroxy glucuronide

• Description :

  Ezetimibe hydroxy glucuronide (SCH 488128) is a trace metabolite detected in dog and human plasma samples after oral administration of Ezetimibe (HY-17376) [1].

• Product Name Alternative :

  SCH 488128; Ezetimibe hydroxy β-D-Glucuronide

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Drug Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ezetimibe-hydroxy-glucuronide.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1O[C@H](C2=CC=C(F)C=C2)CC[C@@H]3[C@@H](C4=CC=C(O)C=C4)N(C5=CC=C(F)C=C5)C3=O

• Molecular Formula :

  C30H29F2NO9

• Molecular Weight :

  585.55

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Anima Ghosal, et al. Identification of human UDP-glucuronosyltransferase enzyme (s) responsible for the glucuronidation of ezetimibe (Zetia) . Drug Metab Dispos. 2004 Mar;32 (3) :314-20.|[2]Ghosal A, et al. Identification of human UDP-glucuronosyltransferase enzyme (s) responsible for the glucuronidation of ezetimibe (Zetia) . Drug Metab Dispos. 2004 Mar;32 (3) :314-20.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [536709-33-8]