(E) -AG 99

• Description :

  (E) -AG 99 ((E) -Tyrphostin 46) is a potent EGFR inhibitor[1].

• Product Name Alternative :

  (E) -Tyrphostin 46; (E) -Tyrphostin AG 99

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  EGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/_E_-AG_99.html

• Purity :

  98.36

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(N)/C(C#N)=C/C1=CC=C(O)C(O)=C1

• Molecular Formula :

  C10H8N2O3

• Molecular Weight :

  204.19

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Yamamoto N, et al. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J Cell Sci. 2006 Nov 15;119 (Pt 22) :4623-33.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EGFR/ErbB1/HER1

• CAS Number :

  [122520-85-8]