(E) -AG 556

• Description :

  (E) -AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production[1][2].

• Product Name Alternative :

  (E) -Tyrphostin AG 556

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H400, H410

• Target :

  EGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/e-ag-556.html

• Purity :

  99.91

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(NCCCCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2

• Molecular Formula :

  C20H20N2O3

• Molecular Weight :

  336.39

• Precautions :

  H301, H400, H410

• References & Citations :

  [1]George J, et al. Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat. Exp Mol Pathol. 2003 Jun;74 (3) :314-8.|[2]Gazit A, et al. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem. 1991 Jun;34 (6) :1896-907.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [133550-41-1]