(E) -AG 556

CAT: 0804-HY-101041-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101041-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E) -AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production[1][2].
CAS Number
[133550-41-1]
Product Name Alternative
(E) -Tyrphostin AG 556
UNSPSC
12352005
Hazard Statement
H301, H400, H410
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/e-ag-556.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NCCCCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2
Molecular Formula
C20H20N2O3
Molecular Weight
336.39
Precautions
H301, H400, H410
References & Citations
[1]George J, et al. Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat. Exp Mol Pathol. 2003 Jun;74 (3) :314-8.|[2]Gazit A, et al. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem. 1991 Jun;34 (6) :1896-907.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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