SN 2

• UNSPSC Description:

  SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM[1]. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV)[2].

• Target Antigen:

  Dengue virus; Flavivirus; TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/SN-2.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC(C=C(C)C=C1C)=C1C2=NOC3C2C4CC3CC4

• Molecular Weight:

  255.35

• References & Citations:

  [1]Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48.|[2]Zhiqiang Xia, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020 Aug 26;104922.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  823218-99-1