SN 2

• Description :

  SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM[1]. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV) [2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Dengue Virus; Flavivirus; TRP Channel

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/SN-2.html

• Purity :

  99.93

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C=C(C)C=C1C)=C1C2=NOC3C2C4CC3CC4

• Molecular Formula :

  C17H21NO

• Molecular Weight :

  255.35

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17 (2) :135-48.|[2]Zhiqiang Xia, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020 Aug 26;104922.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [823218-99-1]