SN-28049

• Description :

  SN-28049 is a new DNA-binding topoisomerase II-directed antitumor agent. SN-28049 activates the p53 pathway. SN-28049 exhibits anticancer activity against colorectal cancer[1][2].

• UNSPSC :

  12352005

• Target :

  DNA Alkylator/Crosslinker; MDM-2/p53; Topoisomerase

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Smiles :

  O=C(NCCN(C)C)C1=CN(C(C2=CC3=CC=CC(C)=C3N=C12)=O)C

• Molecular Formula :

  C19H22N4O2

• Molecular Weight :

  338.40

• References & Citations :

  [1]Chen YY, et al. Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent. Cancer Chemother Pharmacol. 2014 Jul;74 (1) :25-35. |[2]Drummond CJ, et al. Action of SN 28049, a new DNA binding topoisomerase II-directed antitumour drug: comparison with doxorubicin and etoposide. Invest New Drugs. 2011 Oct;29 (5) :1102-10.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Topo II

• CAS Number :

  [492472-30-7]