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CRY2 rabbit pAb

CAT: 0855-ES17214-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES17214-02Size:100 µL
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Background
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Description
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014],
UniProt
Q49AN0
Swiss Prot
Q49AN0
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human CRY2 AA range: 181-231
Target
CRY2
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.
Gene ID (Human)
1408

UniProtKB · Q49AN0

Cryptochrome-2

CRY2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q49AN0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CRY2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DH32, B4DZD6, O75148, Q8IV71
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Biological rhythmsSensory transductionTranscriptionTranscription regulation

Ligand

ChromophoreFADFlavoproteinNucleotide-binding

Cellular component

CytoplasmNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Molecular function

Photoreceptor proteinReceptorRepressor

Technical term

Proteomics identificationReference proteome

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