PF-573228

• Description:

  PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for purified recombinant catalytic fragment of FAK.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; FAK

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/PF-573228.html

• Purity:

  99.32

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C1NC2=C (C=C (NC3=NC=C (C (F) (F) F) C (NCC4=CC=CC (S (=O) (C) =O) =C4) =N3) C=C2) CC1

• Molecular Formula:

  C22H20F3N5O3S

• Molecular Weight:

  491.49

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Slack-Davis JK, et al. Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282 (20) :14845-52.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  869288-64-2