Products for Research Use Only
RegisterLogin

Zoledronate (disodium)

CAT: 0804-HY-13777CSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13777CSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Zoledronate (CGP 42446) disodium is a potent bisphosphonate that effectively inhibits osteoclastogenesis, reducing bone turnover and stabilizing the bone matrix. Zoledronate disodium has demonstrated notable effectiveness in managing Paget's disease of bone by suppressing metabolic activity and alleviating bone pain. Zoledronate disodium is being investigated in the ongoing ZiPP trial for its potential to prevent disease progression in patients with Paget's disease. Zoledronate disodium also exhibits diverse anti-tumor effects in osteosarcoma, further highlighting its multifunctional therapeutic applications.
CAS Number
131654-46-1
Product Name Alternative
CGP 42446 (disodium) ; CGP42446A (disodium) ; ZOL 446 (disodium)
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zoledronate-disodium.html
Smiles
O=P(O)(C(CN1C=NC=C1)(P(O[Na])(O[Na])=O)O)O
Molecular Formula
C5H8N2Na2O7P2
Molecular Weight
316.05
References & Citations
[1]Bisphosphonates in the management of Paget's disease
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Zoledronate disodium

Zoledronate Disodium is the disodium salt form of zoledronate, a synthetic imidazole, third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.

CAS Number131654-46-1
PubChem CID6099949
IUPAC Namedisodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]-2-imidazol-1-ylethyl]phosphinate
Molecular FormulaC5H8N2Na2O7P2
Molecular Weight316.05
Topological Polar Surface Area159
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count18
Formal Charge0
Complexity322
SMILES
C1=CN(C=N1)CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
InChI
InChI=1S/C5H10N2O7P2.2Na/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);;/q;2*+1/p-2
InChIKey
OPQQEYHAVUNQNA-UHFFFAOYSA-L
Chemical Structure
2D Structure
2D structure of Zoledronate disodium
CAS: 131654-46-1
CID: 6099949
Formula: C5H8N2Na2O7P2
MW: 316.05
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight316.05
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass315.96021316
Monoisotopic Mass315.96021316
Topological Polar Surface Area159 Ų
Heavy Atom Count18
Formal Charge0
Complexity322
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-139564DOTA Zoledronate
HY-B0174-01Olsalazine (Disodium)
HY-14521A-01Lometrexol (disodium)
HY-Y0308-01Disodium phosphate
HY-134367Ap2A (disodium)
HY-A0294A-01Ertapenem (disodium)
HY-110385-01CGAMP (disodium)
HY-13718AOglufanide (disodium)
HY-111999BE7766 (disodium)
HY-W010270AAurothiomalate (disodium)

Alternative Products

CatalogName
MBS5813524Zoledronate disodium
GTR19153227-01Zoledronate Disodium Tetrahydrate
574949Zoledronate disodium hydrate
MBS6017819-01Zoledronic Acid, Disodium Salt, Tetrahydrate (Zoledronate Disodium, CGP-42446A)
D535823DOTA Zoledronate
T70305-01Zoledronate trisodium hydrate
MBS8506406-01Zoledronic Acid (Zoledronate)
AR-D07294-01Disodium Dithiocarbamate (Disodium Ethylenebis)
RM-M050800-01Pyrroloquinolinequinone disodium salt; Methoxatin disodium salt
A8332-50R788 disodium

Popular Products