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Zoledronate (disodium)

CAT: 0804-HY-13777CSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13777CSize:1 Each
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Description
Zoledronate (CGP 42446) disodium is a potent bisphosphonate that effectively inhibits osteoclastogenesis, reducing bone turnover and stabilizing the bone matrix. Zoledronate disodium has demonstrated notable effectiveness in managing Paget's disease of bone by suppressing metabolic activity and alleviating bone pain. Zoledronate disodium is being investigated in the ongoing ZiPP trial for its potential to prevent disease progression in patients with Paget's disease. Zoledronate disodium also exhibits diverse anti-tumor effects in osteosarcoma, further highlighting its multifunctional therapeutic applications.
CAS Number
131654-46-1
Product Name Alternative
CGP 42446 (disodium) ; CGP42446A (disodium) ; ZOL 446 (disodium)
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zoledronate-disodium.html
Smiles
O=P(O)(C(CN1C=NC=C1)(P(O[Na])(O[Na])=O)O)O
Molecular Formula
C5H8N2Na2O7P2
Molecular Weight
316.05
References & Citations
[1]Bisphosphonates in the management of Paget's disease
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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