BNS-22

• Description:

  BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity[1].

• UNSPSC:

  12352005

• Target:

  Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bns-22.html

• Purity:

  99.50

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1C=C (CCC) C2=C (OC) C=C (OC) C (C (N3CCCC4=C3C=CC=C4) =O) =C2O1

• Molecular Formula:

  C24H25NO5

• Molecular Weight:

  407.46

• References & Citations:

  [1]Makoto Kawatani, et al. Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling. Chem Biol. 2011 Jun 24;18 (6) :743-51.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Topo II

• CAS Number:

  1151668-24-4