8-Chloroadenosine

8-Chloroadenosine

• CAS Number: 34408-14-5
• UNSPSC Description: 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1].
• Target Antigen: AMPK; Autophagy; Nucleoside Antimetabolite/Analog
• Type: Reference compound
• Related Pathways: Autophagy;Cell Cycle/DNA Damage;Epigenetics;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/8-chloroadenosine.html
• Purity: 99.97
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2Cl)O[C@@H]1CO
• Molecular Weight: 301.69
• References & Citations: [1]Christine M Stellrecht, et al. ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. J Hematol Oncol. 2014 Mar 14;7:23.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: Phase 2