8-Chloroadenosine

• Target:

  Autophagy|||AMPK

• Related Pathways:

  Autophagy|||Chromatin/Epigenetic|||PI3K/Akt/mTOR signaling

• Purity:

  0.9984

• Bioactivity:

  8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Chloroadenosine (NSC-354258) is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226, and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells. 8-Chloroadenosine (NSC-354258) has been shown to deplete ATP and inhibit tumor growth in hematological malignancies as well as in lung and breast cancer cell lines.

• Smiles:

  ClC=1N (C=2C (N1) =C (N) N=CN2) [C@@H]3O[C@H] (CO) [C@@H] (O) [C@H]3O

• Molecular Formula:

  C10H12ClN5O4

• Molecular Weight:

  301.69

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  34408-14-5