2-Chloroadenosine

2-Chloroadenosine

• CAS Number: 146-77-0
• UNSPSC Description: 2-Chloroadenosine, a stable adenosine analogue, protects against long term development of ischaemic cell loss in the rat hippocampus. 2-Chloroadenosine is an apparent competitive inhibitor of uridine influx (apparent Ki=33 μM) and high-affinity nitrobenzylthioinosine binding (apparent Ki=0.18 mM). 2-Chloroadenosine is a transported permeant for the nucleoside transporter in human erythrocytes[1][2].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/2-chloroadenosine.html
• Purity: 99.79
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 33.33 mg/mL (ultrasonic)
• Smiles: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2N=C(Cl)N=C3N)O1
• Molecular Weight: 301.69
• References & Citations: [1]Jarvis SM,2-Chloroadenosine, a permeant for the nucleoside transporter.Biochem Pharmacol. 1985 Sep 15;34(18):3237-41.|[2]Evans MC, et al. An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus.Neurosci Lett. 1987 Dec 29;83(3):287-92.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported