8-Chloroadenosine

CAT: 0804-HY-103400-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103400-01Size:5 mg
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Description
8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1].
CAS Number
[34408-14-5]
Product Name Alternative
8-Cl-Ado
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H332, H335
Target
AMPK; Autophagy; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8-chloroadenosine.html
Purity
99.97
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2Cl)O[C@@H]1CO
Molecular Formula
C10H12ClN5O4
Molecular Weight
301.69
Precautions
H302, H315, H319, H332, H335
References & Citations
[1]Christine M Stellrecht, et al. ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. J Hematol Oncol. 2014 Mar 14;7:23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
AMPK

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