8-Chloroadenosine

• Description :

  8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice[1].

• Product Name Alternative :

  8-Cl-Ado

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H332, H335

• Target :

  AMPK; Autophagy; Nucleoside Antimetabolite/Analog

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/8-chloroadenosine.html

• Purity :

  99.97

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2Cl)O[C@@H]1CO

• Molecular Formula :

  C10H12ClN5O4

• Molecular Weight :

  301.69

• Precautions :

  H302, H315, H319, H332, H335

• References & Citations :

  [1]Christine M Stellrecht, et al. ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells. J Hematol Oncol. 2014 Mar 14;7:23.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  AMPK

• CAS Number :

  [34408-14-5]