TPE-1p

• Description :

  TPE-1p is a cascade-activated AIEgen-peptide probe. TPE-1p self-assembles in aqueous solution to exhibit bright fluorescence in response to alkaline phosphatase (ALP) and ChT-L. TPE-1p can be utilized to noninvasively assess the inhibition efficiency of a ChT-L inhibitor in cells[1].

• UNSPSC :

  12171500

• Target :

  Fluorescent Dye; Phosphatase

• Type :

  Dye Reagents

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tpe-1p.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CC(O)=O)=O)=O)CC2=CC=C(OP(O)(O)=O)C=C2)C3=CC=C(/C(C4=CC=CC=C4)=C(C5=CC=CC=C5)/C6=CC=CC=C6)C=C3

• Molecular Formula :

  C53H49N4O15P

• Molecular Weight :

  1012.95

• References & Citations :

  [1]Jiao Q, et al. Cascade-Activated AIEgen-Peptide Probe for Noninvasively Monitoring Chymotrypsin-like Activity of Proteasomes in Cancer Cells. Anal Chem. 2023 Jun 13;95 (23) :9097-9106.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Dye Reagents

• Clinical Information :

  No Development Reported