Permethrin-d5

• Description:

  Permethrin-d5 (NRDC-143-d5) is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation[1][2].

• Product Name Alternative:

  NRDC-143-d5

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H332-H317-H410

• Target:

  Parasite

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Purity:

  99.21

• Solubility:

  10 mM in DMSO|DMSO : 50mg/mL (ultrasonic)

• Smiles:

  C (=C (Cl) Cl) C1C (C (OCC2=CC (OC3=C (C (=C (C (=C3[2H]) [2H]) [2H]) [2H]) [2H]) =CC=C2) =O) C1 (C) C

• Molecular Formula:

  C21H15D5Cl2O3

• Molecular Weight:

  396.32

• Precautions:

  P261-P264-P270-P271-P272-P273-P280-P302+P352-P304+P340-P330-P362+P364-P391-P501

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Xiao X, et al. Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice. Food Chem Toxicol. 2018 Jan;111:405-416.|[3]Smith LB, et al. CYP-mediated permethrin resistance in Aedes aegypti and evidence for trans-regulation. PLoS Negl Trop Dis. 2018 Nov 19;12 (11) :e0006933.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1794760-19-2