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Permethrin-d6

CAT: 0804-HY-W774926Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W774926Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Permethrin-d6 (NRDC-143-d6) is deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes) [1][2][3][4][5][6][7].
CAS Number
[82523-59-9]
Product Name Alternative
NRDC-143-d6
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Mitochondrial Metabolism; Na+/K+ ATPase; Parasite; Sodium Channel
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Smiles
C(=C(Cl)Cl)C1C(C(OCC2=CC(OC3=CC=CC=C3)=CC=C2)=O)C1(C([2H])([2H])[2H])C([2H])([2H])[2H]
Molecular Formula
C21H14D6Cl2O3
Molecular Weight
397.32
References & Citations
[7]Brander SM, et al. The in vivo estrogenic and in vitro anti-estrogenic activity of permethrin and bifenthrin. Environ Toxicol Chem. 2012 Dec;31 (12) :2848-55.|[8]Omotoso G, et al. Permethrin exposure affects neurobehavior and cellular characterization in rats' brain. Environ Anal Health Toxicol. 2020 Dec;35 (4) :e2020022-0.|[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Xiao X, et al. Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice. Food Chem Toxicol. 2018 Jan;111:405-416.|[3]Smith LB, et al. CYP-mediated permethrin resistance in Aedes aegypti and evidence for trans-regulation. PLoS Negl Trop Dis. 2018 Nov 19;12 (11) :e0006933.|[4]Shelley LK, et al. Immunotoxic and cytotoxic effects of atrazine, permethrin and piperonyl butoxide to rainbow trout following in vitro exposure[J]. Fish Shellfish Immunol. 2012 Aug;33 (2) :455-8.|[5]Gassner B, et al. The pyrethroids permethrin and cyhalothrin are potent inhibitors of the mitochondrial complex I[J]. Journal of Pharmacology and Experimental Therapeutics, 1997, 281 (2) : 855-860.|[6]Kakko I, et al. The synaptosomal membrane bound ATPase as a target for the neurotoxic effects of pyrethroids, permethrin and cypermethrin[J]. Chemosphere. 2003 May;51 (6) :475-80.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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