Permethrin

• UNSPSC Description:

  Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes)[1][2][3][4][5][6][7].

• Target Antigen:

  Mitochondrial Metabolism; Na+/K+ ATPase; Parasite; Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Permethrin.html

• Purity:

  98.0

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(C1C(C)(C)C1/C=C(Cl)\Cl)OCC2=CC=CC(OC3=CC=CC=C3)=C2

• Molecular Weight:

  391.29

• References & Citations:

  [1]Xiao X, et al. Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice. Food Chem Toxicol. 2018 Jan;111:405-416.|[2]Smith LB, et al. CYP-mediated permethrin resistance in Aedes aegypti and evidence for trans-regulation. PLoS Negl Trop Dis. 2018 Nov 19;12(11):e0006933.|[3]Shelley LK, et al. Immunotoxic and cytotoxic effects of atrazine, permethrin and piperonyl butoxide to rainbow trout following in vitro exposure[J]. Fish Shellfish Immunol. 2012 Aug;33(2):455-8.|[4]Gassner B, et al. The pyrethroids permethrin and cyhalothrin are potent inhibitors of the mitochondrial complex I[J]. Journal of Pharmacology and Experimental Therapeutics, 1997, 281(2): 855-860.|[5]Kakko I, et al. The synaptosomal membrane bound ATPase as a target for the neurotoxic effects of pyrethroids, permethrin and cypermethrin[J]. Chemosphere. 2003 May;51(6):475-80.|[6]Brander SM, et al. The in vivo estrogenic and in vitro anti-estrogenic activity of permethrin and bifenthrin. Environ Toxicol Chem. 2012 Dec;31(12):2848-55.|[7]Omotoso G, et al. Permethrin exposure affects neurobehavior and cellular characterization in rats' brain. Environ Anal Health Toxicol. 2020 Dec;35(4):e2020022-0.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  52645-53-1