CIGB-552

• Target :

  NF-?B|||Apoptosis|||ROS

• Related Pathways :

  Apoptosis|||NF-?B|||Immunology/Inflammation

• Bioactivity :

  CIGB-552 is a cell-penetrating peptide with antitumor properties, exhibiting an IC50 of 23 ?M in H460 cells. It increases the level of COMMD1 protein and significantly inhibits the NF-?B signaling pathway. Furthermore, CIGB-552 promotes apoptosis (apoptosis) of tumor cells and induces accumulation of reactive oxygen species (ROS) within them. Additionally, it possesses anti-inflammatory and anti-angiogenic effects. CIGB-552 is applicable in research related to lung and colon cancer.

• Smiles :

  C([C@@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC=3C=4C(NC3)=CC=CC4)C(O)=O)=O)=O)CCCCN)=O)=O)CCCCN)=O)=O)CCCCN)=O)NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](CC5=CC=CC=C5)NC([C@@H](NC(=O)[C@@H]6N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC7=CN=CN7)NC(C)=O)=O)C)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)CCCCN)=O)CCC6)[C@@H](C)O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCCN)=O)C=8C=9C(NC8)=CC=CC9

• Molecular Formula :

  C131H198N38O24

• Molecular Weight :

  2689.21

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1630763-23-3