MK-8325 (dihydrochloride)

• UNSPSC Description:

  MK-8325 (dihydrochloride) is an inhibitor of HCV NS5A with oral activity. MK-8325 exhibits minimal inhibition on hERG at the concentration of 30 mM[1].

• Target Antigen:

  HCV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/mk-8325-dihydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@H](C(C)C)NC(OC)=O)N1C[Si](C[C@H]1C2=NC3=CC=C4C(C=CC(C5=CC=C(C6=CN=C([C@@H]7CC(CN7C([C@H](C(C)C)NC(OC)=O)=O)(F)F)N6)C=C5)=C4)=C3N2)(C)C.Cl.Cl

• Molecular Weight:

  915.93

• References & Citations:

  [1]Anilkumar G Nair, et al. MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV. Bioorg Med Chem Lett. 2018, 28,10.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  1334314-19-0