MK-0354

• UNSPSC Description:

  MK-0354 is a specific GPR109a receptor agonist, acting on hGPR109a/mGPR109a, with EC50 of 1.65 μM and 1.08 μM respectively, and has no effect on GPR109b.

• Target Antigen:

  GPR109A

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/MK-0354.html

• Purity:

  99.73

• Solubility:

  DMSO : ≥ 36 mg/mL

• Smiles:

  C12=C(CCC2)C(C3=NN=NN3)=NN1

• Molecular Weight:

  176.18

• References & Citations:

  [1]Semple G, et al. 3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice. J. Med. Chem., 2008, 51 (16), pp 5101-5108|[2]Lai E1, et al. Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans. J Clin Lipidol. 2008 Oct;2(5):375-383.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Phase 2

• CAS Number:

  851776-28-8