Human PPT1 (recombinant)

Human PPT1 (recombinant)_x000D_ Catalog number: B2016745_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 32.7 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Palmitoyl-protein Hydrolase 1, Palmitoyl-protein Hydrolase 1, CLN1_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Lu JY, Hu J, Hofmann SL. Human recombinant palmitoyl-protein thioesterase-1 (PPT1) for preclinical evaluation of enzyme replacement therapy for infantile neuronal ceroid lipofuscinosis Mol Genet Metab. 2010 Apr;99(4):374-8._x000D_ 2: Dearborn JT, Ramachandran S, Shyng C, Lu JY, Thornton J, Hofmann SL, Sands MS. Histochemical localization of palmitoyl protein thioesterase-1 activity Mol Genet Metab. 2016 Feb;117(2):210-6._x000D_ 3: Lyly A, von Schantz C, Salonen T, Kopra O, Saarela J, Jauhiainen M, Kyttälä A, Jalanko A. Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1)--distinct characteristics in neurons BMC Cell Biol. 2007 Jun 12;8:22._x000D_ 4: Nelvagal HR, Eaton SL, Wang SH, Eultgen EM, Takahashi K, Le SQ, Nesbitt R, Dearborn JT, Siano N, Puhl AC, Dickson PI, Thompson G, Murdoch F, Brennan PM, Gray M, Greenhalgh SN, Tennant P, Gregson R, Clutton E, Nixon J, Proudfoot C, Guido S, Lillico SG, Whitelaw CBA, Lu JY, Hofmann SL, Ekins S, Sands MS, Wishart TM, Cooper JD. Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep J Clin Invest. 2022 Oct 17;132(20):e163107._x000D_ 5: Wang R, Borazjani A, Matthews AT, Mangum LC, Edelmann MJ, Ross MK. Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme Biochemistry. 2013 Oct 29;52(43):7559-74._x000D_ 6: Cho S, Dawson PE, Dawson G. Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells J Neurosci Res. 2000 Oct 15;62(2):234-40._x000D_ 7: Meng L, Sin N, Crews CM. The antiproliferative agent didemnin B uncompetitively inhibits palmitoyl protein thioesterase Biochemistry. 1998 Jul 21;37(29):10488-92._x000D_ 8: Hofmann SL, Das AK, Lu JY, Soyombo AA. Positional candidate gene cloning of CLN1 Adv Genet. 2001;45:69-92._x000D_ 9: Henderson MX, Wirak GS, Zhang YQ, Dai F, Ginsberg SD, Dolzhanskaya N, Staropoli JF, Nijssen PC, Lam TT, Roth AF, Davis NG, Dawson G, Velinov M, Chandra SS. Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation Acta Neuropathol. 2016 Apr;131(4):621-37._x000D_ 10: Khaledi H, Liu Y, Masi S, Gelb MH. Detection of Infantile Batten Disease by Tandem Mass Spectrometry Assay of PPT1 Enzyme Activity in Dried Blood Spots Anal Chem. 2018 Oct 16;90(20):12168-12171. _x000D_ _x000D_ Products Related to Human PPT1 (recombinant) can be found at Proteins

9000-83-3

Catalog Number: B2016745 (50 µg)

0.15

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0.5