α-Amylase/α-Glucosidase-IN-10

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T60255-5mg	α-Amylase/α-Glucosidase-IN-1

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804-HY-162373

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α-Amylase/α-Glucosidase-IN-10

UNSPSC Description: α-Amylase/α-Glucosidase-IN-10 (compound 5d) is an α-amylase and α-glucosidase inhibitor (IC50: 30.39 μM and 65.1 μM) with potential diabetes inhibitory effects. α-Amylase/α-Glucosidase-IN-10 exhibits high gastrointestinal (GI) absorption in ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) prediction. While α-Amylase/α-Glucosidase-IN-10 acts as a substrate for P-gp and does not cross the blood-brain barrier (BBB), there may be a risk of central nervous system side effects[1].
Target Antigen: Amylases; Glycosidase; P-glycoprotein
Type: Reference compound
Related Pathways: Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Applications: Metabolism-sugar/lipid metabolism
Field of Research: Metabolic Disease
Assay Protocol: https://www.medchemexpress.com/α-amylase-α-glucosidase-in-10.html
Solubility: 10 mM in DMSO
Smiles: O=C(/C1=N\NC(COC2=C(C)C=CC=C2C[C@H]3ON([C@]4(C[C@H](C)CC[C@H]4C(C)C)N(C)C5=O)[C@@]5([H])C3)=O)NC6=C1C=CC(Cl)=C6
Molecular Weight: 622.15
References & Citations: [1]Ghannay S, et al. Identification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: Design, synthesis, in vitro and multiscale molecular modeling approaches. Heliyon. 2024 Feb 11;10(4):e25911.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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Cat	Name
HY-162373	α-Amylase/α-Glucosidase-IN-10
HY-162673	α-Amylase/α-Glucosidase-IN-16
HY-156380	α-Amylase/α-Glucosidase-IN-6
HY-149557	α-Amylase/α-Glucosidase-IN-5
HY-147711	α-Amylase/α-Glucosidase-IN-1
HY-163439	α-Amylase/α-Glucosidase-IN-12
HY-162635	α-Amylase/α-Glucosidase-IN-14
HY-162634	α-Amylase/α-Glucosidase-IN-15
HY-162390	α-Amylase/α-Glucosidase-IN-11
HY-161355	α-Amylase/α-Glucosidase-IN-9