Guanfu base A

CAT: 0804-HY-N1483-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N1483-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6) . Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current[2].
CAS Number
[1394-48-5]
UNSPSC
12352005
Target
Potassium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/guanfu-base-a.html
Purity
98.10
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@]12C3[C@]45[C@@]([C@@H]6O)([H])C1(CC([C@@]6([H])[C@H]2OC(C)=O)=C)C[C@@]7([H])[C@]4([H])[C@@](C)(C[C@H](OC(C)=O)C5)C[N@]37
Molecular Formula
C24H31NO6
Molecular Weight
429.51
References & Citations
[1]Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43 (5) :713-24.|[2]Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59 (1) :77-83.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-148717NSC363998 (free base)
HY-139806SRA880 (free base)
HY-117256Gabazine (free base)
HY-106277Fasitibant (free base)
HY-152852-01Mefatinib (free base)
HY-129706LY127210 (free base)
HY-120421SW116 (free base)
HY-116031ATC0175 (free base)
HY-106518Adimolol (free base)
HY-105154Proxodolol (free base)

Alternative Products

CatalogName
BUP01528-01Guanfu base A
MF-0022496Guanfu base H
MF-0022497-01Guanfu base I
BUP24037-01Guanfu base G
DM 1266-01Mycoplasma Agar Base (PPLO Agar Base)
RM-C190650-01Caspofungin (Base)
GC208001-5kgTris Base
abx076556-01Lapatinib (base)
abx082498-01Tris-base
sc-205885DVinorelbine base

Popular Products