PROTAC EGFR degrader 11
CAT:
804-HY-161633-04
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PROTAC EGFR degrader 11
- CAS Number: 3034244-71-5
- UNSPSC Description: PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 Ki of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.
- Target Antigen: EGFR; FAK; PROTACs
- Type: Reference compound
- Related Pathways: JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/protac-egfr-degrader-11.html
- Smiles: O=C1C(C2=C(F)C=C(N3CCC(OCCN(CC4)CCN4C(CC5)CCN5C(C(CC)=C6)=CC(OC)=C6NC7=NC=C(Cl)C(NC8=CC=C(OC)C=C8N(S(=O)(C)=O)C)=N7)CC3)C=C2)CCC(N1)=O
- Molecular Weight: 991.61
- References & Citations: [1]Han W, et al., Compound for targeted protein degradation, and use thereof. WO2024072178A1
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported