PROTAC EGFR degrader 3

PROTAC EGFR degrader 3

• CAS Number: 2768472-28-0
• UNSPSC Description: PROTAC EGFR degrader 3 is a potent PROTAC EGFR degrader. PROTAC EGFR degrader 3 shows excellent cellular activity against the H1975 and HCC827 cells with high selectively. PROTAC EGFR degrader 3 shows that the lysosome is involved in the degradation process of EGFR mutant degradation[1].
• Target Antigen: EGFR; PROTACs
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-egfr-degrader-3.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: C=CC(N1CCC[C@@H](C1)N2C3=C(N=C2NC4=CC=CC=C4)C=NC(NC5=CC=C(C=C5)N6CCN(CC6)CCCCCCCC(N[C@H](C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C=C8)C9=C(N=CS9)C)C)=O)=O)C(C)(C)C)=O)=N3)=O
• Molecular Weight: 1092.40
• References & Citations: [1]Zhao HY, et al. Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands. J Med Chem. 2022; 65(6):4709-4726.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported