PROTAC EGFR degrader 8
CAT:
804-HY-153901-05
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PROTAC EGFR degrader 8
- CAS Number: 2925923-46-0
- UNSPSC Description: PROTAC EGFR degrader 8 (T-184) is a PROTAC EGFR degrader. PROTAC EGFR degrader 8 degrades EGFR in HCC827 cell with a DC50 of 15.56 nM. PROTAC EGFR degrader 8 inhibits H1975, PC-9, HCC827 cell growth with IC50s of 7.72 nM, 121.9 nM, 14.21 nM. PROTAC EGFR degrader 8 can be used for research of cancer, especially NSCLC[1].
- Target Antigen: EGFR; PROTACs
- Type: Reference compound
- Related Pathways: JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/protac-egfr-degrader-8.html
- Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(C1=C(NC2=NC(NC3=CC=C(N4CCN(CC4)C(CN5CCN(CC5)C6=CC=C(NC7C(NC(CC7)=O)=O)C=C6)=O)C=C3OC)=NC=C2Cl)C=CC=C1)NC
- Molecular Weight: 796.32
- References & Citations: [1]Liang, Apeng, et al. Compounds for EGFR protein degradation and uses thereof. Patent. CN116135852.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported