PROTAC EGFR degrader 4

PROTAC EGFR degrader 4

• CAS Number: 2882845-50-1
• UNSPSC Description: PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR.PROTAC EGFR degrader 4 induces EGFRdel19 and EGFRL858R/T790M degradation with DC50s of 0.51 and 126 nM, respectively. PROTAC EGFR degrader 4 significantly inhibits growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. Induced EGFR degradation is related to autophagy[1].
• Target Antigen: Autophagy; EGFR; PROTACs
• Type: Reference compound
• Related Pathways: Autophagy;JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-egfr-degrader-4.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC=C7N=C(N(C7=N6)C8CCCC8)NC9=CC=CC=C9)=O)=O)O)=O
• Molecular Weight: 995.29
• References & Citations: [1]Hong-Yi Zhao, Discovery of potent small molecule PROTACs targeting mutant EGFR. Eur J Med Chem. 2020 Dec 15;208:112781.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported